Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
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منابع مشابه
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
Target-specific, mechanism-oriented in vitro assays post a promising alternative to traditional animal toxicology studies. Here we report the first comprehensive analysis of the Tox21 effort, a large-scale in vitro toxicity screening of chemicals. We test ∼ 10,000 chemicals in triplicates at 15 concentrations against a panel of nuclear receptor and stress response pathway assays, producing more...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms10425